Multi-item a supply chain production inventory model of time dependent production rate and demand rate under space constraint in fuzzy environment

In this paper, we have developed an integrated production inventory model for two echelon supply chain consisting of one vendor and one retailer. Production rate and demand rate of retailer and customer are time dependent. Idle time cost of the vendor has been considered. Multi-item inventory has been considered. In integrated inventory model average cost has been calculated under limitation on stroge space. Two echelon supply chain fuzzy inventory model has been solved by various techniques like as Fuzzy programming technique with hyperbolic membership functions (FPTHMF), Fuzzy non-linear programming technique (FNLP) and Fuzzy additive goal programming technique (FAGP),  weighted Fuzzy non-linear programming technique (WFNLP) and weighted Fuzzy additive goal programming technique (WFAGP). A numerical example is illustrated to test the model. Finally to make the model more realistic, sensitivity analysis has been shown

Multi objective fuzzy inventory model with deterioration, price and time dependent demand and time dependent holding cost

In this paper, we have formulated an inventory model with time dependent holding cost, selling price as well as time dependent demand. Multi-item inventory model has been considered under limitation on storage space. Due to uncertainty all the require cost parameters are taken as generalized trapezoidal fuzzy number. Our proposed multi-objective inventory model has been solved by using fuzzy programming techniques which are FNLP, FAGP, WFNLP and WFAGP methods. A numerical example is provided to demonstrate the application of the model. Finally to illustrate the model and sensitivity analysis and graphical representation have been shown.

PROCESS OPTIMIZATION OF FRP SANDWICH COMPOSITE STRUCTURE FOR ENGINEERING APPLICATION

“Composites are the combination of a reinforcement fibre in a thermoset polymer resin matrix, where the reinforcement has an aspect ratio that enables the transfer of loads between fibres, and the fibres are chemically bonded to the resin matrix.” FRP (fibre reinforced plastic) Sandwich structure are defined as a three layer type of construction a thick layer known as core and two thin polymer layer known as face . In automobile and aerospace industries FRP composites are used due to numerous advantage like mechanical, chemical, thermal properties and light weight. The mechanical, thermal chemical properties can be optimize by stabilizing the core[1][2]. For this study various raw material characterization done .Aluminium honeycomb used as a Core material (25mm thick) and Epoxy prepreg (layer used as a face sheet material) & PU foam provide housing for core [5]. The experiment conducted according to raw material characterization test report . by autoclave curing At a particular temperature, pressure ,vacuum with respect to time process optimized ,sandwich cured and stabilized. Finally the test conducted According to ASTMD & DIN standard as a result it shows that the stabilized FRP sandwich having excellent mechanical properties compare to core crushing FRP sandwich

Management of infected non-unions of long bones using limb reconstruction system (LRS) fixator

Background: Due to increasing number of high-energy traumatic events, the incidence of complex and compound fractures are also in the rise. Such fractures are often exposed to various environmental contaminants, inadequate debridement and sometimes erroneous decision making leading to cases of infected nonunions. Eradication of infection in such cases and achieving union may sometimes pose serious challenge to orthopaedic surgeons. Presence of comminution, bone gap or deformity can seriously complicate the situation. No definite surgical technique has been found to be full proof in dealing with these infected nonunion cases. In this scenario the limb reconstruction system (LRS) fixator is emerging as a useful option for infected nonunions with deformity or gap nonunion.Methods: Twenty seven cases of infected nonunions involving tibia (n=19), femur (n=7) and humerus (n=1) were treated by LRS fixators after debridement of the infected nonunion site. Flap cover procedure was done as per necessity. Bone gaps and limb length discrepancies were dealt with bone transport or limb lengthening by the LRS instrument. Weight-bearing and removal of fixator was decided according to the radiological evidence of healing.Results: All the nonunions and the regeneration sites healed uneventfully, although the union time was varied (range, 21-52 weeks). Commonest complication was pin-tract infection and pain. The mean lower extremity functional score (LEFS) was 60.3 out of 80. Conclusions: LRS fixator is an excellent tool for management of infected nonunions which is easy to apply, comfortable for the patient with minimum complications and predictable as well as reproducible outcomes

Evaluation of bioavailability of three extracts of a less known ethno-medicinal plant, Thottea tomentosa from Assam

55-64Plants of the genus Thottea have been established as wild ethno-medicinal plants. The plant, Thottea tomentosa also has the illness recuperative property. However, there are no such reports so far on the solvent polarity based performances of the plant. Hence, the current work deals with the assessment of bioavailabilities like qualitative phyto-chemical screening, total phenol contents, total flavonoid contents, antioxidant efficiency, and antimicrobial efficiency using three solvents of diverse polarities like hexane, chloroform, and methanol. The phenolic compositions of methanol extract of stem and leaf; 374.99±3.84 and 260.55±4.00 mg GAE per gram of dry weight of extract respectively and correlate by linking antioxidant activities of methanol extract of the stem and leaf (DPPH; IC50 202.39±0.92 and 254.37±1.47 μg/mL respectively). Thus, probable antimicrobial activities of methanol extract of stem and leaf were also study, than that of other extracts. Methanol stem extract against the microbes; Bacillus subtilis (MTCC 1427), Escherichia coli (MTCC 1195), Pseudomonas aeruginosa (MTCC 1688), Staphylococcus aureus susp. aureus (MTCC 1430), Streptococcus pneumonie (MTCC 2672), Aspergillus niger (Lab isolates) and Candida albicans (MTCC 4748) exhibited highest zone of inhabitation (ZOI). Therefore, these results indicate that T. tomentosa can be satisfying the dietetic demand for the food and drug production

Operative outcome of high energy pilon fractures: a retrospective comparison between internal fixation and Ilizarov external fixation

Background: Pilon fractures are serious injuries with many devastating soft-tissue complications associated with them. Deciding a definite treatment plan has always proved a challenge. Comparative studies between the various surgical techniques used for pilon fractures are uncommon and consensus is yet to be reached regarding the best surgical option. Purpose of this study is to retrospectively compare the operative results (complications, functional and radiographic outcomes) of pilon fractures treated either with internal fixation or Ilizarov ring fixators.Methods: Forty-six patients with pilon fractures were retrospectively studied; twenty-one of them had minimal invasive fixation by ankle spanning Ilizarov fixators and 25 patients had internal fixations by either minimal invasive plate osteosynthesis (MIPO) or by open reduction.  The patients were followed-up for a mean of 34 months (range, 24-51 months).Results: The internal fixation group had a higher incidence of soft-tissue complications and deep infections. In comparison the Ilizarov group had only superficial pin-tract infections but no other soft-tissue complications. Although the Ilizarov group had a higher incidence of malreduction and malunion in their series compared to the internal fixation group, there was no significant difference in the AOFAS ankle function score (p-value 0.2922) between the two groups after a follow-up of 2-4 years.Conclusions: The moderately long term functional outcome appears to be similar in both internal fixation and Ilizarov groups. But the Ilizarov technique is less likely to cause any serious peri-operative soft-tissue complications or deep infection. Familiarity of the surgeon with a particular technique should also be considered during surgical decision making.

Rescue of a chimeric rinderpest virus with the nucleocapsid protein derived from peste-des-petits-ruminants virus: use as a marker vaccine

The nucleocapsid (N) protein of all morbilliviruses has a highly conserved central region that is thought to interact with and encapsidate the viral RNA. The C-terminal third of the N protein is highly variable among morbilliviruses and is thought to be located on the outer surface and to be available to interact with other viral proteins such as the phosphoprotein, the polymerase protein and the matrix protein. Using reverse genetics, a chimeric rinderpest virus (RPV)/peste-des-petits-ruminants virus (PPRV) was rescued in which the RPV N gene open reading frame had been replaced with that of PPRV (RPV–PPRN). The chimeric virus maintained efficient replication in cell culture. Cattle vaccinated with this chimeric vaccine showed no adverse reaction and were protected from subsequent challenge with wild-type RPV, indicating it to be a safe and efficacious vaccine. The carboxyl-terminal variable region of the rinderpest N protein was cloned and expressed in Escherichia coli. The expressed protein was used to develop an indirect ELISA that could clearly differentiate between RPV- and PPRV-infected animals. The possibility of using this virus as a marker vaccine in association with a new diagnostic ELISA in the rinderpest eradication programme is discussed

Robust estimation of bacterial cell count from optical density

Optical density (OD) is widely used to estimate the density of cells in liquid culture, but cannot be compared between instruments without a standardized calibration protocol and is challenging to relate to actual cell count. We address this with an interlaboratory study comparing three simple, low-cost, and highly accessible OD calibration protocols across 244 laboratories, applied to eight strains of constitutive GFP-expressing E. coli. Based on our results, we recommend calibrating OD to estimated cell count using serial dilution of silica microspheres, which produces highly precise calibration (95.5% of residuals <1.2-fold), is easily assessed for quality control, also assesses instrument effective linear range, and can be combined with fluorescence calibration to obtain units of Molecules of Equivalent Fluorescein (MEFL) per cell, allowing direct comparison and data fusion with flow cytometry measurements: in our study, fluorescence per cell measurements showed only a 1.07-fold mean difference between plate reader and flow cytometry data

Multi objective fuzzy inventory model with deterioration, price and time dependent demand and time dependent holding cost

In this paper, we have formulated an inventory model with time dependent holding cost, selling price as well as time dependent demand. Multi-item inventory model has been considered under limitation on storage space. Due to uncertainty all the require cost parameters are taken as generalized trapezoidal fuzzy number. Our proposed multi-objective inventory model has been solved by using fuzzy programming techniques which are FNLP, FAGP, WFNLP and WFAGP methods. A numerical example is provided to demonstrate the application of the model. Finally to illustrate the model and sensitivity analysis and graphical representation have been shown.